A Complete Guide To Pharmaceutical Organic Chemistry Ii

A Complete Guide to Pharmaceutical Organic Chemistry II (BP301T) as per the PCI syllabus

What you’ll learn
Write the structure, name and the type of isomerism of the organic compound
write the reaction, name the reaction and orientation of reactions
account for reactivity/stability of compounds
prepare organic compounds
apply the chemical methodologies for the preparation of chemical compounds
design novel chemical methods for the synthesis of molecules of medicinal uses.
Requirements
No prior experience needed – I’ll teach you everything you need to know
A mobile/computer with access to the internet
No paid software required
Description
Scope:This subject deals with general methods of preparation and reactions of some organic compounds. Reactivity of organic compounds are also studied here. The syllabus emphasizes on mechanisms and orientation of reactions. Chemistry of fats and oils are also included in the syllabus.Objectives:Upon completion of the course the student shall be able to:- write the structure, name and the type of isomerism of the organic compound- write the reaction, name the reaction and orientation of reactions- account for reactivity/stability of compounds,- prepare organic compoundsCourse content:Unit IBenzene and its derivativesA. Analytical, synthetic and other evidences in the derivation of structure of benzene, Orbital picture, resonance in benzene, aromatic characters, Huckel’s ruleB. Reactions of benzene – nitration, sulphonation, halogenation- reactivity, Friedelcrafts alkylation- reactivity, limitations, Friedelcrafts acylation.C. Substituents, effect of substituents on reactivity and orientation of mono substituted benzene compounds towards electrophilic substitution reactionD. Structure and uses of DDT, Saccharin, BHC and ChloramineUnit IIPhenols – Acidity of phenols, effect of substituents on acidity, qualitative tests, Structure and uses of phenol, cresols, resorcinol, naphtholsAromatic Amines – of amines, effect of substituents on basicity, and synthetic uses of aryl diazonium saltsAromatic Acids –Acidity, effect of substituents on acidity and important reactions of benzoic acid.Unit IIIFats and Oilsa. Fatty acids – reactions. b. Hydrolysis, Hydrogenation, Saponification and Rancidity of oils, Drying oils. c. Analytical constants – Acid value, Saponification value, Ester value, Iodine value, Acetyl value, Reichert Meissl (RM) value – significance and principle involved in their determination.Unit IVPolynuclear hydrocarbons:a. Synthesis, reactionsb. Structure and medicinal uses of Naphthalene, Phenanthrene, Anthracene, Diphenylmethane, Triphenylmethane and their derivativesUnit VCyclo alkanesStabilities – Baeyer’s strain theory, limitation of Baeyer’s strain theory,Coulson and Moffitt’s modification, Sachse Mohr’s theory (Theory of strainless rings), reactions of cyclopropane and cyclobutane only

Overview

Section 1: Unit 1: Benzene and its derivatives

Lecture 1 01 Introduction to Benzene and its derivatives

Lecture 2 02 Nomenclature of derivatives of Benzene

Lecture 3 03 Discovery and Methods of Preparation of Benzene

Lecture 4 04 Evidences in the derivation of the structure of Benzene

Lecture 5 05 Kekule’s Representation of Benzene

Lecture 6 06 The Resonance Model of Benzene

Lecture 7 07 Molecular Orbital Model of Benzene

Lecture 8 08 Aromaticity and Huckel Rule

Lecture 9 09 Classification of Aromatic molecules

Lecture 10 10 Non-aromatic and Anti-aromatic molecules

Lecture 11 11 Electrophilic Substitution Reactions of Benzene

Lecture 12 12 Sulphonation of Benzene

Lecture 13 13 Nitration of Benzene

Lecture 14 14 Halogenation – Chlorination of Benzene

Lecture 15 15 Halogenation – Iodination of Benzene

Lecture 16 16 Friedel Crafts Alkylation of Benzene

Lecture 17 17 Friedel Crafts Acylation of Benzene

Lecture 18 18 Effect of substituent on Reactivity

Lecture 19 19 Inductive and Resonance Effect

Lecture 20 20 Effect of Substituent on Orientation

Lecture 21 21 Theory of Orientation Effect of Substituent

Lecture 22 22 Structure and Uses of DDT

Lecture 23 23 Structure and Uses of BHC

Lecture 24 24 Structure and Uses of Sachharin

Lecture 25 25 Structure and Uses of Chloramine

Any Undergraduate / Postgraduate / Researcher / chemistry student,Any Undergraduate / Postgraduate / Researcher / pharmacy student